The VANGUARD project aims to generate a bioartificial vascularized and immunoprotected pancreas that can be transplanted into non-immunosuppressed patients, combining advanced elements of tissue engineering such as 3D organoids, hydrogel design, the assembly of bioartificial organs and gene editing via CRISPR-Cas9.

This approach will produce cell therapy in the form of an advanced therapy medicinal product (ATMP), which can significantly improve the treatment of type 1 diabetes.

The project involves a consortium with 9 partners from 5 European countries.

In Italy, 8.5% of cancer cases are associated with viral infections; among these, the strongest link has been found with human Papillomavirus (HPV), which contributes to 5% of tumours worldwide.

The 4DInSiDe project sets out to improve some features of UFSD sensors, a new concept in sensor design to measure both the space and time resolution of a charged particle, with greater precision.

Specifically, the project is aimed at applications where 100% of active sensitive area is necessary (sensors with pixels of just a few hundred microns or fewer) and/or the reduction of the total thickness of the sensor of optic entrance window (allowing the use of these sensors for detection of low-energy x-ray photons).

Haemophilia A is a genetic disease that affects blood coagulation, and is caused by mutations of the Factor (F) VIII gene. At the present moment in time, treatment consists of substitution therapy with recombinant or plasma-derived FVIII inhibitors, administered as prophylaxis or according to need. The two biggest limitations of this treatment are the high costs and development of antibodies which neutralise FVIII activity in around 30% of patients, who must then be treated with other coagulants (meaning even greater treatment costs).

Project in collaboration with the University of Turin (Prof.P.D'Amelio is Head of the UNITO department).

The project looks at the role of the ICOS/ICOSL system in bone and metabolic fragility in elderly people with Fragility Syndrome. The ICOS/ICOSL system was studied at length in the past regarding immune response, but more recent data collected by the project members demonstrates that it is also involved in bone metabolism.